Discussion
Diagnosis With Brief Discussion
- Diagnosis
- amyloidosis
- Radiologic Findings
- Chest CT: Multifocal nodular thickening with calcifications at the trachea (involving the posterior membrane), Lt main bronchus, LLLobar bronchus, RML medial segmental bronchus and RLL lateral basal segmental bronchus
The patient underwent a bronchoscopic biopsy at the left main bronchus and the pathology showed amyloid deposition.
- Brief Review
- Amyloidosis:
A group of diseases resulting from the extracellular accumulation of abnormal protein in tissues and organs throughout the body.
Primary, secondary (chronic infection or inflammation to malignancy, e.g., rheumatoid arthritis, Sjögren syndrome), or hereditary
Airway involvement often occurs in isolation (than with systemic amyloidosis)
M > F, 50-60s
Dyspnea, cough, wheezing, hemoptysis, and recurrent pneumonia
Five-year survival rates: 30% to 50%
Proximal airway disease have worse prognosis
CT:
Airway wall thickening
Airway wall may be high in attenuation (calcification or ossification)
May involve the tracheal posterior membrane
- References
- Müller’s Imaging of the Chest 2nd edition
- Keywords
- Tracheobronchial amyloidosis,